Endocrine Abstracts

Introduction: No study has evaluated the effect of cytokines on the prototype beta chemokine (C-C motif) ligand (CCL)2 in Graves’ ophthalmopathy (GO), nor of peroxisome proliferator-activated receptor (PPAR)alpha activation on this chemokine secretion in fibroblasts or preadipocytes in GO.Design and methods: We have tested the interferon (IFN)gamma and tumor necrosis factor (TNF)alpha effect on CCL2, and for comparison on the prototype alpha chemoki...

Context. The routine measurement of serum calcitonin (CT) has been proposed for patients with nodular goiter (NG), to detect unsuspected medullary thyroid carcinoma (MTC) before surgery. Objective To assess the prevalence of hypercalcitoninemia and MTC in NG patients; to compare the ability of CT measurement and fine needle aspiration cytology (FNAC) to predict MTC; to identify age groups of NG patients who should be better candidates than others to undergo routine measurement...